Avastin
Active substance: Bevacizumab
Manufacturer: Genentech (USA) / Roche (Worldwide)
Extract from the prescribing information:
"AVASTIN administration can result in the development of gastrointestinal 8 perforation, in some instances resulting in fatality."
The above has been extracted from the Avastin prescribing information on the Genentech webpages.